Photodynamic therapy in gastrointestinal cancer

✍ Scribed by Dr. Strashimir Karanov; Maria Shopova; Hristo Getov

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 407 KB
• Volume: 11
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.1900110502

✦ Synopsis

Six patients with an early stage of gastrointestinal (GI) cancer (TINoMo, stage I) were successfully treated by photodynamic therapy (PDT) as follows: esophagus-1, stomach-2, rectum-3. The patients were photosensitized 72 hrs rior to treatment with pure venous infusion. Argon-pumped dye laser light at 0.630 pm wavelength was used in single and multiple treatment sessions with the power density ranging from 0.015 to 0.192 W.m-2 and a dose varying from 0.320 to 1.600 kJ.m-2. Tumor eradication (complete response) was obtained in each of the patients. No early or late treatment related complications were recorded. The patients were followed-up in the course of 7-16 months after treatment and no local recurrence or general development of disease (metastases) were reported. PDT in the early stage of GI carcinoma was recognized as a radical therapeutic method in clinical oncology.