Six patients with an early stage of gastrointestinal (GI) cancer (TINoMo, stage I) were successfully treated by photodynamic therapy (PDT) as follows: esophagus-1, stomach-2, rectum-3. The patients were photosensitized 72 hrs rior to treatment with pure venous infusion. Argon-pumped dye laser light
Dose measurements in photodynamic therapy of cancer
โ Scribed by Prof. A. Edward Profio PhD; Daniel R. Doiron
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 462 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0196-8092
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โฆ Synopsis
A theory and method for prediction and measurement of the effective absorbed dose in photodynamic therapy of cancer is presented. The method depends on measuring the concentration of the photosensitizer (such as dihematorporphyrin ether), the flux density of the light, and the relative photodynamic effectiveness. Previous, less exact methods relied on specifying the drug dosage and delay after injection and or the irradiance at the surface or power from an interstitial fiber. The new formulation should permit closer control of the effective absorbed dose and better clinical results with photodynamic therapy.
๐ SIMILAR VOLUMES
The application of phthalocyanine derivatives in medicine as photosensitizers for photodynamic therapy of cancer diseases is reviewed. The emphasis is on the work of Russian authors, which is less covered in the scientific literature.
Using normal rat liver we investigated the depth of necrosis induced by photodynamic therapy when different light doses and photosensitizer (Photogemยฎ) concentrations. All experiments were done with a fluence rate of 250 mW/cm^2^. Photosensitizer concentration was varied from 1.0, 1.5, 2.0, and 5.0