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Photochemistry of fluorophenyl azides in diethylamine. Nitrene reaction versus ring expansion

✍ Scribed by Elisa Leyva; Rubén Sagredo


Book ID
104208649
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
343 KB
Volume
54
Category
Article
ISSN
0040-4020

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Although alkyl azides can react with ketones to torm ring-expanded lactams, the reaction suffers from poor generality and the need to use powerful Lewis acid promotion. The reactions of 1,2-and 1,3-hydroxyalkyl azides with ketones yield N-hydroxyalkyl lactams in high yields under the action of proti