Injectable formulation of disodium 1-[2-
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David J. Waterhouse; Joseph E. Saavedra; Keith M. Davies; Michael L. Citro; Xia
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Article
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2006
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John Wiley and Sons
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English
β 105 KB
PROLI/NO is an agent of structure XN(O)==NONa (X = L-prolyl) whose 2-s half-life for nitric oxide (NO) release at physiological pH makes it an excellent prodrug for localizing NO's therapeutic effects at the site of application, but a difficult one to formulate and certify as pure. Despite its extra