## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
✦ LIBER ✦
Photochemische reduktion des 7-nitro-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-on und der drei isomeren N-acetyl-nitraniline
✍ Scribed by H.J. Roth; M. Adomeit
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 145 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near