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Photo-reversal of the circadian rhythm in the proliferative activity of the mouse small intestine

✍ Scribed by Curtis P. Sigdestad; S. Lesher


Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
284 KB
Volume
78
Category
Article
ISSN
0021-9541

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✦ Synopsis


Abstract

Mice (C57Bl) were placed for 35 days in a room with reversed light cycle; lights came on at 1800 hours and off at 0600 hours. At six hour intervals throughout the day three mice were injected with tritiated thymidine and sacrificed 30 minutes later. Crypts were dissected for radioautography and determination of disintegrations per minute per crypt, the number of cells in mitosis and the number of cells synthesizing DNA was determined. The results reported clearly demonstrate reversal of the circadian rhythm in the parameters tested.


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