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Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

✍ Scribed by Andrei V Khokhlatchev; Bertram Canagarajah; Julie Wilsbacher; Megan Robinson; Mark Atkinson; Elizabeth Goldsmith; Melanie H Cobb

Book ID: 117268058
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 411 KB
Volume: 93
Category: Article
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81189-7

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## Abstract Extracellular signal‐regulated kinase (ERK) 1/2 signaling is involved in tumor cell survival through the regulation of Bcl‐2 family members. To explore this further and to demonstrate the central role of the mitochondria in the ERK1/2 pathway we used the HeLa cellular model where apopto