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Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer

✍ Scribed by Ha, S; Iqbal, N J; Mita, P; Ruoff, R; Gerald, W L; Lepor, H; Taneja, S S; Lee, P; Melamed, J; Garabedian, M J; Logan, S K

Book ID
120225457
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
730 KB
Volume
32
Category
Article
ISSN
0950-9232

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Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b