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Phosphorylation of Histones Triggers DNA Fragmentation in Thymocyte Undergoing Apoptosis Induced by Protein Phosphatase Inhibitors

โœ Scribed by Riyo Enomoto; Rina Koyamazaki; Yumi Maruta; Motoko Tanaka; Kazuhiro Takuma; Koichi Mori; Eibai Lee

Book ID
118769208
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
205 KB
Volume
4
Category
Article
ISSN
1522-4724

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This study examined the role of protein phosphorylation in TNF induction of apoptosis in several tumor cell lines by testing the effects of agents that either stimulate or inhibit protein phosphorylation. The serine-threonine phosphatase inhibitors, okadaic acid (OW) and calyculin A (CIA), synergist