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Phosphorylation of histone H2AX at M phase in human cells without DNA damage response

✍ Scribed by Yosuke Ichijima; Ryo Sakasai; Naoyuki Okita; Kinji Asahina; Shuki Mizutani; Hirobumi Teraoka

Book ID: 116291292
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 334 KB
Volume: 336
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2005.08.164

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## Abstract ## Background The induction of DNA double‐strand breaks (DSBs) in chromatin triggers histone H2AX phosphorylation (on __Ser__‐139) by ATM‐, ATR‐, or DNA‐dependent protein kinases (DNA‐PK). Phosphorylated H2AX, denoted as γH2AX, can be detected immunocytochemically using an antibody tha

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