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Phosphorylation of epidermal keratin proteins by cyclic AMP-dependent protein kinase

✍ Scribed by S. Inohara; S. Sagami

Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
340 KB
Volume
275
Category
Article
ISSN
0340-3696

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✦ Synopsis

Recent evidence suggests that cyclic AMP may be involved in the regulation of epidermal proliferation and keratinization [1 -3]. The diverse biological effects of cyclic AMP are considered to be mediated by cyclic AMP-dependent protein kinase and by sequent phosphorylation of specific substrate proteins [4,5]. Intermediate filament proteins such as desmin and vimentin have been shown to be phosphorylated by cyclic AMP-dependent protein kinase and it is suggested that this phenomenon may play an important role in biological regulatory events [6]. Epidermal keratin is one of the intermediate filament proteins [7], but the protein kinase responsible for the phosphorylation of this protein has not been elucidated. In this paper, we describe a 60,000 dalton (60 K) epidermal keratin phosphorylated by cyclic AMP-dependent protein kinase in an in vivo system.

Guinea pigs (300-400g) were purchased from a

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