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Phosphorus pentoxide in organic synthesis, VII. Synthesis of 3-aryl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imines

✍ Scribed by Girgis, Nabih S. ;Jørgensen, Anker ;Pedersen, Erik B.

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
399 KB
Volume
1983
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The title compounds 2 were prepared by treating 2‐(acetylamino)‐3‐pyrrolecarbonitriles 1 with a mixture of phosphorus pentoxide, N,N‐dimethylcyclohexanamine, and an appropriate arylamine hydrochloride at 150–180°C. The importance of using absolutely anhydrous arylamine hydrochlorides is stressed because failing this, 4‐(arylamino)pyrrolo[2,3‐d]pyrimidines 4 can be formed as by‐products. – The results from pesticide and anticancer screenings are reported.

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