Phosphoramidate ProTides of 2′- C -Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties
✍ Scribed by McGuigan, Christopher; Gilles, Arnaud; Madela, Karolina; Aljarah, Mohamed; Holl, Sabrina; Jones, Sarah; Vernachio, John; Hutchins, Jeff; Ames, Brenda; Bryant, K. Dawn; Gorovits, Elena; Ganguly, Babita; Hunley, Damound; Hall, Andrea; Kolykhalov, Alexander; Liu, Yule; Muhammad, Jerry; Raja, Nicholas; Walters, Robin; Wang, Jin; Chamberlain, Stanley; Henson, Geoffrey
- Book ID
- 120343558
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 880 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Apixaban is a potent inhibitor of blood coagulation Factor Xa in the late stages of development. [^14^C]apixaban was synthesized with the 14C label in the two different lactam ring systems within the molecule for various __in vitro__ and __in vivo__ metabolism studies. A nine‐step synth