✦ LIBER ✦

Phospholipase A 2 as a Target Protein for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Crystal Structure of the Complex Formed between Phospholipase A 2 and Oxyphenbutazone at 1.6 Å Resolution †

✍ Scribed by Singh, Nagendra; Jabeen, Talat; Somvanshi, Rishi K.; Sharma, Sujata; Dey, Sharmistha; Singh, Tej P.

Book ID: 127153636
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 429 KB
Volume: 43
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi0483561

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Specific binding of non-steroidal anti-i

Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 Å resolution

✍ Singh, Nagendra ;Jabeen, Talat ;Sharma, Sujata ;Somvanshi, R. K. ;Dey, Sharmisth 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 493 KB

Type IIA secretory phospholipase A 2 (PLA 2 ) enzymes catalyze the hydrolysis of the sn-2 ester bond of glycerophospholipids to release fatty acids and lysophospholipids. In order to elucidate the role of PLA 2 in inflammatory disorders and to determine the mode of binding of non-steroidal antiinfla

Aspirin induces its anti-inflammatory ef

Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A 2 : Crystal structure of the complex formed between phospholipase A 2 and aspirin at 1.9 Å resolution

✍ Singh, Rajendra Kumar; Ethayathulla, A.S.; Jabeen, Talat; Sharma, Sujata; Kaur, 📂 Article 📅 2005 🏛 Informa plc 🌐 English ⚖ 446 KB

Crystal structure of the complex formed

Crystal structure of the complex formed between a group I Phospholipase A2 and a naturally occurring fatty acid at 2.7 Å resolution

✍ Garima Singh; Jayasankar Jasti; K. Saravanan; Sujata Sharma; Punit Kaur; A. Srin 📂 Article 📅 2005 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 215 KB

First Structural Evidence of a Specific

First Structural Evidence of a Specific Inhibition of Phospholipase A2 by α-Tocopherol (Vitamin E) and its Implications in Inflammation: Crystal Structure of the Complex Formed Between Phospholipase A2 and α-Tocopherol at 1.8 Å Resolution

✍ Vikas Chandra; Jayasankar Jasti; Punit Kaur; Ch. Betzel; A. Srinivasan; T.P. Sin 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 426 KB

Design of Specific Peptide Inhibitors fo

Design of Specific Peptide Inhibitors for Group I Phospholipase A 2 : Structure of a Complex Formed between Phospholipase A 2 from Naja naja sagittifera (Group I) and a Designed Peptide Inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 Å Resolution Reveals Unique Features †,‡

✍ Singh, Rajendra Kumar; Vikram, P.; Makker, Jyoti; Jabeen, Talat; Sharma, Sujata; 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 315 KB

Simultaneous inhibition of anti-coagulat

Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 Å resolution reveals the presence of the new common ligand-binding site

✍ Nagendra Singh; Ramasamy Prem Kumar; Sanjit Kumar; Sujata Sharma; Rafia Mir; Pun 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

## Abstract A novel ligand‐binding site with functional implications has been identified in phospholipase A~2~ (PLA~2~). The binding of non‐steroidal anti‐inflammatory agent indomethacin at this site blocks both catalytic and anti‐coagulant actions of PLA~2~. A group IIA PLA~2~ has been isolated fr