Phosphoinositides in Subcellular Targeting and Enzyme Activation

✍ Scribed by R. J. Botelho, C. C. Scott, S. Grinstein (auth.), Professor Harald Stenmark (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2004
Tongue: English
Leaves: 214
Series: Current Topics in Microbiology and Immunology 282
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The reversible recruitment of intracellular protein complexes to membranes is essential for immune cell functions, including chemotaxis, phagocytosis and signalling. Such recruitment is often controlled by phosphorylated derivatives of phosphatidylinositol, known as phosphoinositides. These lipids also serve to activate enzyme systems that carry out complex reactions such as chromatin remodelling and pre-mRNA procesing. This issue of Current Topics in Microbiology and Immunology presents an overview of how phosphoinositides function in protein recruitment and enzyme activation and presents physiologically important examples of protein-phosphoinositide interactions.

✦ Table of Contents

Front Matter....Pages i-ix
Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation....Pages 1-30
Regulation of Endocytosis by Phosphatidylinositol 4,5-Bisphosphate and ENTH Proteins....Pages 31-47
Membrane Targeting by Pleckstrin Homology Domains....Pages 49-88
Protein Targeting to Endosomes and Phagosomes via FYVE and PX Domains....Pages 89-115
Regulation of the Actin Cytoskeleton by PI(4,5)P 2 and PI(3,4,5)P 3 ....Pages 117-163
Roles of PI3K in Neutrophil Function....Pages 165-175
Nuclear Phosphoinositides and Their Functions....Pages 177-206
Back Matter....Pages 207-212

✦ Subjects

Immunology

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