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Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin-stimulated platelets

โœ Scribed by Muriel Laffargue; Jeannie M.F. Ragab-Thomas; Ashraf Ragab; Joel Tuech; Karine Missy; Laurent Monnereau; Ulrich Blank; Monique Plantavid; Bernard Payrastre; Patrick Raynal; Hugues Chap


Book ID
117110280
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
235 KB
Volume
443
Category
Article
ISSN
0014-5793

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Thrombin-stimulated phosphatidylinositol
โœ Mohamed R. Sayed; Michael P. Sheid; Christiaan M. Stevens; Vincent Duronio ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 157 KB

In this study, we investigated the activation of a new member of the focal adhesion kinase family of tyrosine kinases, the proline-rich tyrosine kinase, or PYK2, in platelets. We show that PYK2 is tyrosine phosphorylated and its activity is increased during early stages of platelet aggregation. This