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Phosphodiesterase-4 Inhibitors in the Treatment of Inflammatory Lung Disease

โœ Scribed by Dr Domenico Spina

Book ID
119928024
Publisher
Springer International Publishing AG
Year
2003
Tongue
English
Weight
325 KB
Volume
63
Category
Article
ISSN
0012-6667

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[Handbook of Experimental Pharmacology] Phosphodiesterases as Drug Targets Volume 204 || Phosphodiesterase Inhibitors in the Treatment of Inflammatory Diseases
โœ Francis, Sharron H.; Conti, Marco; Houslay, Miles D. ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Springer Berlin Heidelberg ๐ŸŒ German โš– 201 KB

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that