[Handbook of Experimental Pharmacology]
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Francis, Sharron H.; Conti, Marco; Houslay, Miles D.
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Article
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2011
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Springer Berlin Heidelberg
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German
โ 201 KB
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that