Electrical activation of the heart requires intercellular transfer of current through gap junctions connecting individual cardiac myocytes. Using a combination of light and electron microscopic techniques and molecular approaches, we have characterized the number, size, and spatial distribution of i
✦ LIBER ✦
Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes
✍ Scribed by Johannes P. Hofgaard; Kathrin Banach; Sarah Mollerup; Helene Korvenius Jørgensen; Søren Peter Olesen; Niels-Henrik Holstein-Rathlou; Morten Schak Nielsen
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 437 KB
- Volume
- 457
- Category
- Article
- ISSN
- 0031-6768
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## Abstract Intracellular Na^+^ concentration ([Na^+^]~i~) is very important in modulating the contractile and electrical activity of the heart. Upon electrical excitation of the myocardium, voltage‐dependent Na^+^ channels open, triggering the upstroke of the action potential (AP). During the AP,