✦ LIBER ✦

Structural and molecular determinants of intercellular coupling in cardiac myocytes

✍ Scribed by H. Lee Kanter; Eric C. Beyer; Dr. Jeffrey E. Saffitz

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 809 KB
Volume: 31
Category: Article
ISSN: 1059-910X
DOI: 10.1002/jemt.1070310505

No coin nor oath required. For personal study only.

✦ Synopsis

Electrical activation of the heart requires intercellular transfer of current through gap junctions connecting individual cardiac myocytes. Using a combination of light and electron microscopic techniques and molecular approaches, we have characterized the number, size, and spatial distribution of intercellular connections at gap junctions in cardiac myocytes and have also cloned, sequenced, and elucidated the subcellular distribution of three physiologically distinct gap junction channel proteins. In this review, we present evidence to suggest that t,he spatial distribution of myocyte interconnections and the molecular composition of gap junction channels may confer distinct conduction properties on specific tissues of the mammalian heart such as atrial and ventricular myocardium, and the nodes and bundles of the cardiac conduction system.

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