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Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases

✍ Scribed by Barbara Adamo; Allison M Deal; Emily Burrows; Joseph Geradts; Erika Hamilton; Kimberly L Blackwell; Chad Livasy; Karen Fritchie; Aleix Prat; J Chuck Harrell; Matthew G Ewend; Lisa A Carey; C Ryan Miller; Carey K Anders

Book ID
118726834
Publisher
BioMed Central
Year
2011
Tongue
English
Weight
683 KB
Volume
13
Category
Article
ISSN
1465-5411

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Retinol decreases phosphatidylinositol 3
Retinol decreases phosphatidylinositol 3-kinase activity in colon cancer cells
✍ Eun Young Park; Erik T. Wilder; Joseph E. Chipuk; Michelle A. Lane πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 414 KB

## Abstract Previously, we showed that retinol inhibited __all‐trans__‐retinoic acid (ATRA)‐resistant human colon cancer cell invasion via a retinoic acid receptor‐independent mechanism. Because phosphatidylinositol 3‐kinase (PI3K) regulates cell invasion, the objective of the current study was to