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Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia

✍ Scribed by N. Shioda; T. Ishigami; F. Han; S. Moriguchi; M. Shibuya; Y. Iwabuchi; K. Fukunaga


Book ID
116788210
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
1010 KB
Volume
148
Category
Article
ISSN
0306-4522

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re