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Phosphatidylinositol 3′-Kinase Is Associated with a Serine Kinase That Is Activated by Okadaic Acid

✍ Scribed by Keith A. Cengel; Jonathan P. Godbout; Gregory G. Freund

Book ID
115581476
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
133 KB
Volume
242
Category
Article
ISSN
0006-291X

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In this study, we investigated the activation of a new member of the focal adhesion kinase family of tyrosine kinases, the proline-rich tyrosine kinase, or PYK2, in platelets. We show that PYK2 is tyrosine phosphorylated and its activity is increased during early stages of platelet aggregation. This