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Phosphatidylcholine and Phosphatidylethanolamine Behave as Substrates of the Human MDR1 P-Glycoprotein †

✍ Scribed by Bosch, Irene; Dunussi-Joannopoulos, Kyriaki; Wu, Rui-Lian; Furlong, Stephen T.; Croop, James

Book ID
127330665
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
322 KB
Volume
36
Category
Article
ISSN
0006-2960

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Mice homozygous for a disruption in the Mdr2 gene (Mdr2 (-/-) mice) lack the Mdr2 P-glycoprotein (P-gp) in the canalicular membrane of the hepatocyte and are unable to excrete phosphatidylcholine into the bile. These mice develop a nonsuppurative cholestatic liver disease, presumably caused by the h