## Monoclonal antibodies (MAbs ) recognizing external epitopes of the human MDRl P-glycoprotein have been used both for the detection of multidrug-resistant cells and as specific inhibitors of P-glycoprotein-mediated multidrug resistance. Using a panel of recently developed transfected or transgen
Topology of MDR1-P-glycoprotein as indicated by epitope mapping of monoclonal antibodies to human MDR cells
โ Scribed by Maurizio Cianfriglia; Francesca Poloni; Claudia Signoretti; Giulia Romagnoli; Marina Tombesi; Franco Felici
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 405 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0920-9069
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A new murine monoclonal antibody (MAb), MM6.15, to human MDRl P-glycoprotein was found to be reactive in ELISA with synthetic peptides selected from the predicted sequences of the first, fourth and sixth extracellular loop of MDRI-Pglycoprotein. In order to precisely define the MM6. 15-binding site,
Fatty acid ester surfactants Cremophor EL and Solutol H S I 5 were described earlier as modulators of multidrug resistance mediated by MDR I P-glycoprotein (Pgp). We have shown that the most active components of these polydisperse surfactants are fatty acid-polyethylene glycol-fatty acid diesters (F