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Phorbol esters stimulate the transport of anionic amino acids in cultured human fibroblasts

✍ Scribed by Renata Franchi-Gazzola; Ovidio Bussolati; Rossana Visigalli; Bianca Maria Rotoli; Patrizia A. Rossi; Guido G. Guidotti; Gian C. Gazzola

Book ID
117055187
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
433 KB
Volume
173
Category
Article
ISSN
0006-291X

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Chronic lymphocytic leukemia (CLL) B-lymphocytes have a unique and specific diminution of L-system (leucine favoring) amino acid uptake; the maximal velocity is approximately 10% of normal B-lymphocytes. Treatment of CLL Bcells with the maturational agent, tetradecanoyl phorbol acetate, results in r