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Phorbol ester (TPA) reduces prostaglandin E2-stimulated cAMP production by desensitization of prostaglandin E2receptors in a clonal osteoblast-like cell line, MOB 3-4

✍ Scribed by Tomoyuki Kawase; Michiaki Orikasa; Akitoshi Suzuki

Book ID
110559076
Publisher
Springer
Year
1991
Tongue
English
Weight
772 KB
Volume
48
Category
Article
ISSN
1432-0827

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Effects of prostaglandin E2 and F2Ξ± on c
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✍ Tomoyuki Kawase; Michiaki Orikasa; Akitoshi Suzuki πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 816 KB

Prostaglandin E, (PGE,, 5 ng/ml to 5 pg/ml) induced a dose-dependent increase in cAMP accumulation, inositol phosphates (IPS) accumulation, and cytoplasmic free Ca2+ ([Ca2+li) in a clonal osteoblast-like cell line, MOB 3-4. In contrast, prostaglandin F,a (PGF a, 5 ng/ml to 5 p,g/ml) stimulated incre