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Phorbol ester mediated activation of inducible nitric oxide synthase results in platelet profilin nitration

✍ Scribed by S. Kasina; R. Wasia; Aneesa Fasim; K.V.N. Radhika; Surya S. Singh

Book ID: 116789996
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 214 KB
Volume: 14
Category: Article
ISSN: 1089-8603
DOI: 10.1016/j.niox.2005.09.008

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## Abstract A proinflammatory cytokine IFN‐γ stimulates microglia in the injured brain; however, signaling pathways for IFN‐γ‐mediated microglia activation are not well characterized. In the present study, a protein kinase C (PKC) activator phorbol 12‐myristate 13‐acetate (PMA) acts in concert with