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Phloretin, phloridzin and glucose inhibition of a phosphatase on the stromata of rabbit erythrocytes

โœ Scribed by Laris, Philip C. ;Novinger, Gordon ;Calaprice, John

Publisher
Wiley (John Wiley & Sons)
Year
1960
Tongue
English
Weight
202 KB
Volume
55
Category
Article
ISSN
0095-9898

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โœฆ Synopsis

Several authors have proposed "carrier mechanisms" for sugar transport in human erythrocytes (Le Fevre, '54; Wilbrandt, '54; Widdas, '52) and in rabbit erythrocytes (Park et al., '56). Although the proposed site of interaction of membrane and sugar has not been identified, some of its properties are known, i.e., phloretin and phloridzin act as competitors with sugar for the carrier in human erythrocytes according to Le Fevre ('54). While studying the properties of a phosphatase of rabbit erythrocyte stromata with adenosine triphosphate as substrate, it was determined that phloretin, phloridzin, and glucose inhibit the phosphatase activity. There is a similarity between the inhibitory capacities of these substances as measured in these investigations and their relative affinities for the "carrier" as measured by Le Fevre ('54).

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