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Phenylalanine derivatives as catalysts in the enantioselective addition of diethylzinc to benzaldehydes

✍ Scribed by Ruxandra D. Ionescu; Anna Blom; Torbjörn Frejd

Book ID
104359982
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
667 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

A series of mono and bis b-amino alcohols derived from phenylalanine were synthesised and their application as chiral catalysts in the asymmetric ethylation of aromatic aldehydes in the presence of diethylzinc investigated.

📜 SIMILAR VOLUMES

Chiral ferrocenyl amino alcohols as anal
Chiral ferrocenyl amino alcohols as analogues of norephedrine catalysts for enantioselective addition of diethylzinc to benzaldehyde
✍ Stéphanie Bastin; Jacques Brocard; Lydie Pélinski 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 146 KB

Optically active ferrocenyl amino alcohols have been prepared from commercially available l-alaninol and l-leucinol. They have been used in catalytic amounts as chiral ligands in the addition of diethylzinc to benzaldehyde. 1-Phenylpropanol has thus been obtained in up to 95% enantiomeric excess.