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Phenotypic heterogeneity and parental origin of extra chromosome 21 in Down syndrome

โœ Scribed by Mamta Muranjan; Tejasvi Chaudhari; Babu Rao Vundinti


Book ID
107697547
Publisher
Indian Academy of Pediatrics
Year
2010
Tongue
English
Weight
456 KB
Volume
47
Category
Article
ISSN
0019-6061

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Parental origin of the extra chromosome
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Chromosome 21 fluorescent heteromorphisms were studied in 42 patients with Down's syndrome, their parents and their siblings. Included in this number are two instances of an aunt and niece affected with trisomy 21, and one of affected siblings. One case has a de novo 21/21 translocation. Blood group

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The number of 21 chromosomes of 15 individuals with Down's syndrome and their parents were examined in an attempt to determine the parental origin of the extra number 21 chromosome and the stage of meiosis at which nondisjunction occurred. Chromosomes were stained with quinacrine hydrochloride and p