Phenotypic heterogeneity and parental origin of extra chromosome 21 in Down syndrome
โ Scribed by Mamta Muranjan; Tejasvi Chaudhari; Babu Rao Vundinti
- Book ID
- 107697547
- Publisher
- Indian Academy of Pediatrics
- Year
- 2010
- Tongue
- English
- Weight
- 456 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0019-6061
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๐ SIMILAR VOLUMES
Chromosome 21 fluorescent heteromorphisms were studied in 42 patients with Down's syndrome, their parents and their siblings. Included in this number are two instances of an aunt and niece affected with trisomy 21, and one of affected siblings. One case has a de novo 21/21 translocation. Blood group
The number of 21 chromosomes of 15 individuals with Down's syndrome and their parents were examined in an attempt to determine the parental origin of the extra number 21 chromosome and the stage of meiosis at which nondisjunction occurred. Chromosomes were stained with quinacrine hydrochloride and p