Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats
β Scribed by Bing Shi; James E. Heavner; Charles E. Reigel; Y. James Kao; Alan D. Kaye
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 60 KB
- Volume
- 362
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Acute administration (0.4-12 mumol/kg, i.p.) of the NMDA antagonist D(-)CPPene (3-(2-carboxypiperazin-4-yl)propenyl-1-phosphonic acid; molecular weight = 250.2) dose-dependently reduced the incidence of sound-induced clonic seizures in genetically epilepsy-prone (GEP) rats. The ED50 value against cl
Genetically epilepsy-prone rats (GEPR) are an animal model of generalized motor seizures. The underlying causes of the predisposition to seizures in GEPR have not been fully determined. The brainstem auditory system is critical for audiogenic seizures in GEPR, and neurophysiological abnormalities ha