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Phenotypic and genotypic switch in Philadelphia-positive, BCR-positive blast crisis of chronic myeloid leukemia

✍ Scribed by V. Callea; F. Morabito; P. Francia di Celle; F. Ronco; A. Carbone; F. Nobile; R. Foa


Book ID
114791609
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
508 KB
Volume
48
Category
Article
ISSN
0902-4441

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We have isolated the 3Ј BCR breakpoint junction of a complex BCR-ABL1 rearrangement found in leukemic cells with a cytogenetically normal karyotype, and the corresponding germline fragment that spanned the 3Ј BCR recombination site. Fluorescence in situ hybridization localized the 3Ј BCR recombinati