๐”– Scriptorium
โœฆ   LIBER   โœฆ

๐Ÿ“

Phenotypes and genotypes: the search for influential genes

โœ Scribed by International Society for Computational Biology.;Bogdan, Malgorzata;Frommlet, Florian;Ramsey, David Mark


Publisher
Springer London
Year
2016
Tongue
English
Series
Computational biology volume 18
Category
Library

โฌ‡  Acquire This Volume

No coin nor oath required. For personal study only.

โœฆ Synopsis


This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Topics and features: Presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical) Reviews the latest advances in the field, highlighting the advantages and shortcomings of the currently most commonly used methods Illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data Discusses open challenges that remain to be solved in the future Includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics This important work is essential reading for researchers and graduate students wishing to enter the field of statistical genetics and/or interested in statistical issues related to the analysis of high-dimensional data. No prior background knowledge of genetics is required, although some basic mathematical and computer science skills are assumed. Dr. Florian Frommlet is a researcher in the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, Austria. Dr. Maล‚gorzata Bogdan is an Associate Professor in the Institute of Mathematics at Wrocล‚aw University, Poland. Dr. David Ramsey is a Senior Lecturer in the Department of Operations Research at Wrocล‚aw University of Technology, Poland.

โœฆ Table of Contents


Introduction A Primer in Genetics Statistical Methods in High Dimensions Statistical Methods of QTL Mapping for Experimental Populations Statistical Analysis of GWAS Appendix A: Basic Statistical Distributions Appendix B: Basic Methods of Estimation Appendix C: Principles of Statistical Testing Appendix D: Elements of Bayesian Statistics Appendix E: Other Statistical Methods

โœฆ Subjects


Genotype;Gรฉnotypes;Phenotype;Phรฉnotypes;Geฬnotypes;Pheฬnotypes


๐Ÿ“œ SIMILAR VOLUMES


Phenotypes and Genotypes: The Search for
โœ Frommlet, Florian;Bogdan, Ma Gorzata;Ramsey, David ๐Ÿ“‚ Library ๐Ÿ“… 2016 ๐Ÿ› Springer ๐ŸŒ English

This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with exp

Phenotypes and Genotypes: The Search for
โœ Florian Frommlet, Maล‚gorzata Bogdan, David Ramsey (auth.) ๐Ÿ“‚ Library ๐Ÿ“… 2016 ๐Ÿ› Springer-Verlag London ๐ŸŒ English

<p><p>This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association wi

Genotype to Phenotype
โœ J. J. Goodship (Editor); S. Malcolm (Editor) ๐Ÿ“‚ Library ๐Ÿ“… 2001 ๐Ÿ› Garland Science

<p>This new edition builds on the success of the first by reviewing the increased understanding of the mechanisms of gene action in humans, focusing particularly on those derived from the study of genetic diseases. It deals mainly with the fundamental aspects of gene arrangement and expression rathe

Genotype Phenotype Coupling. Methods and
โœ Stefan Zielonka (ed.), Simon Krah (ed.) ๐Ÿ“‚ Library ๐Ÿ“… 2020 ๐Ÿ› Humana Press ๐ŸŒ English

<p><p>This volume aims at providing state-of-the-art protocols detailing ribosome display, cDNA display, phage display, yeast surface display, and mammalian display. Chapters guide readers through methods and protocols on in vitro methods over prokaryotic display systems, lower eukaryotes, and mamma

Genotype Phenotype Coupling: Methods and
โœ Stefan Zielonka, Simon Krah ๐Ÿ“‚ Library ๐Ÿ“… 2023 ๐Ÿ› Humana Press ๐ŸŒ English

<span>This detailed new edition broadens the scope of the first edition by moving beyond classical display technologies. This book explores methodologies for the generation of natively paired antibody libraries, single cell technologies, alternative scaffolds, and in silico antibody sequence assessm

Genotype Phenotype Coupling: Methods and
โœ Stefan Zielonka; Simon Krah ๐Ÿ“‚ Library ๐Ÿ“… 2023 ๐Ÿ› Springer Nature ๐ŸŒ English

This detailed new edition broadens the scope of the first edition by moving beyond classical display technologies. This book explores methodologies for the generation of natively paired antibody libraries, single cell technologies, alternative scaffolds, and in silico antibody sequence assessments a