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Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

✍ Scribed by Braeuning, Albert; Gavrilov, Alina; Schwarz, Michael

Book ID: 126851522
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 65 KB
Volume: 229
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2014.06.515

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## Abstract Tumor cells express tumor‐associated antigens (TAAs), which can serve as targets for the immune system. However, the majority of TAAs are overexpressed products of normal cellular genes; as such, self‐tolerance mechanisms have hindered their use for the induction of effective antitumor