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Phenobarbital-Mediated Tumor Promotion in Transgenic Mice with Humanized CAR and PXR

✍ Scribed by Braeuning, A.; Gavrilov, A.; Brown, S.; Wolf, C. R.; Henderson, C. J.; Schwarz, M.

Book ID: 121866848
Publisher: Oxford University Press
Year: 2014
Tongue: English
Weight: 708 KB
Volume: 140
Category: Article
ISSN: 1096-6080
DOI: 10.1093/toxsci/kfu099

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## Abstract Tumor cells express tumor‐associated antigens (TAAs), which can serve as targets for the immune system. However, the majority of TAAs are overexpressed products of normal cellular genes; as such, self‐tolerance mechanisms have hindered their use for the induction of effective antitumor