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Phenacetin-induced Papillary Damage in Experimental Animals

โœ Scribed by ABRAHAMS, C.; RUBENSTEIN, A. H.; LEVIN, N. W.

Book ID
109631737
Publisher
Nature Publishing Group
Year
1963
Tongue
English
Weight
638 KB
Volume
200
Category
Article
ISSN
0028-0836

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โœ R. A. Axelsen ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 456 KB

Homozygous Gunn rats, mutant Wistars genetically lacking glucuronyl transferase, develop renal papillary necrosis after single oral doses of aspirin and of phenacetin. The lesion appears significantly more frequently with aspirin than phenacetin, and at lower doses. The model is a convenient one wit