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Analgesic-induced renal papillary necrosis in the gunn rat: The comparative nephrotoxicity of aspirin and phenacetin

โœ Scribed by R. A. Axelsen

Book ID
104504945
Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
456 KB
Volume
120
Category
Article
ISSN
0022-3417

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โœฆ Synopsis

Homozygous Gunn rats, mutant Wistars genetically lacking glucuronyl transferase, develop renal papillary necrosis after single oral doses of aspirin and of phenacetin. The lesion appears significantly more frequently with aspirin than phenacetin, and at lower doses. The model is a convenient one with which to study analgesic nephrotoxicity.

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