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Phase I/pharmacokinetic study of intraperitoneal teniposide (VM 26)

โœ Scribed by Canal, Pierre; Bugat, Roland; Chatelut, Etienne; Pinel, Marie-Claire; Houin, Georges; Plusquellec, Yves; Carton, Michel


Book ID
122434927
Publisher
Elsevier Science
Year
1989
Weight
629 KB
Volume
25
Category
Article
ISSN
0277-5379

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Nine patients with ovarian carcinoma and malignant ascites treated with IV teniposide chemotherapy (30 mg/m2/30 min) entered this study. Plasma and peritoneal fluid levels were measured by an HPLC method with electrochemical detection. Plasma decay kinetics followed a triexponential function. A high