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Phase I and pharmacokinetic study of intraperitoneal topotecan

✍ Scribed by Steven C. Plaxe; Randolph D. Christen; John O'Quigley; Patricia S. Braly; James L. Freddo; Edward McClay; Dennis Heath; Stephen B. Howell


Book ID
110231601
Publisher
Springer US
Year
1998
Tongue
English
Weight
59 KB
Volume
16
Category
Article
ISSN
0167-6997

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Aclacinomycin-A (Aclarubicin) is a relatively new anthracycline antibiotic with potential activity against ovarian cancer. Eight patients with various malignancies (4 ovary, 1 breast and ovary, 1 breast, 1 colon, 1 leiomyosarcoma) and intraperitoneal disease were treated in a Phase I trial with esca