Phase I/II trials of WR-2721 and cis-platinum
โ Scribed by Donna Glover; John H. Glick; Clare Weiler; Kevin Fox; Andrew Turrisi; Morton M. Kligerman
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 528 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0360-3016
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Patients undergoing x-ray therapy to the pelvis have intestinal symptoms proportional to the volume treated and the dose delivered. WR-2721, S-2 (3-aminopropylaminoethyl) phosphorothioic acid, is an organic thiophosphate compound that selectively protects normal tissues against radiation effects. A
Forty-nine patients with regionally confined recurrent malignancy were treated with intra-arterial cisdiamminedichloro platinum I1 in a Phase 1-11 trial. A safe starting dose of 120 mg/m\* was established. An overall response rate of 45% was noted with significant responses observed among patients w