Phase I/II study of treatment with dendritic cell vaccines in patients with disseminated melanoma
β Scribed by Peter Hersey; ScottW. Menzies; GaryM. Halliday; Tam Nguyen; MargaretL. Farrelly; Chitra DeSilva; Margaret Lett
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 214 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0340-7004
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Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that can be used for vaccination purposes, to induce a specific T-cell response in vivo against melanomaassociated antigens. We have shown that the sequential use of early-acting hematopoietic growth factors, stem cell factor, IL
Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reas