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Phase II study of high-dose tamoxifen (NSC-180973) in patients with disseminated malignant melanoma

✍ Scribed by Edward T. Creagan; James N. Ingle; David L. Ahmann; Stephanie J. Green

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
206 KB
Volume
49
Category
Article
ISSN
0008-543X

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✦ Synopsis

Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate to severe nausea occurred in 24% of patients. In the dose and schedule used in this study, tamoxifen is ineffective in patients with advanced malignant melanoma and prior chemotherapy exposure.

Cancer 49:1353-1354. 1982.

NDOCRINE FACTORS may have some influence on

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