𝔖 Bobbio Scriptorium
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A phase II study of autologous irradiated tumor cells plus BCG in patients with metastatic malignant melanoma

✍ Scribed by J. Frederick Laucius; Audley J. Bodurtha; Michael J. Mastrangelo; Robert E. Bellet

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
285 KB
Volume
40
Category
Article
ISSN
0008-543X

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✦ Synopsis

Eighteen patients with surgically incurable metastatic malignant melanoma were treated with a mixture of irradiated (15,000 rads) autologous tumors cells (1-2 X 10(8)) and BCG (Glaxo, 2-4.5 X 10(6) organisms), which was injected intradermally (in five divided doses) every 2 weeks (X5). Four of 18 (22%) evaluable patients achieved objective remissions. It is concluded that this treatment regimen does not have general clinical application because the remissions were infrequent, of shor duration (median, 3 months) and occurred only in patients with minimal, nonvisceral tumor burdens.

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