✦ LIBER ✦

Hyperthermia for the treatment of patients with malignant germ cell tumors : A Phase I/II study in ten children and adolescents with recurrent or refractory tumors

✍ Scribed by Rüdiger Wessalowski; Heidi Kruck; Hildegard Pape; Thomas Kahn; Reinhart Willers; Ulrich Göbel

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 151 KB
Volume: 82
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980215)82:4<793::aid-cncr24>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

waves in combination with platinum-based chemotherapy in ten children and 4 Institute of Statistics, Heinrich-Heine Univeradolescents with recurrent or refractory GCTs. sity, Du ¨sseldorf, Germany.

RESULTS.

Seven of ten patients with recurrent or refractory GCTs had objective responses. Of these, two patients had a partial response and five patients had a complete response.

CONCLUSIONS.

The results of the current study found that combined RHT and platinum-based chemotherapy can be used in children and adolescents. This regimen was found to induce objective tumor response in 70% of study patients with recurrent or refractory GCTs. The results thus far are encouraging and the study has been extended to patients with a poor response to first-line treatment.

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