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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

✍ Scribed by Ott, Patrick A.; Carvajal, Richard D.; Pandit-Taskar, Neeta; Jungbluth, Achim A.; Hoffman, Eric W.; Wu, Bor-Wen; Bomalaski, John S.; Venhaus, Ralph; Pan, Linda; Old, Lloyd J.; Pavlick, Anna C.; Wolchok, Jedd D.


Book ID
111985161
Publisher
Springer US
Year
2012
Tongue
English
Weight
490 KB
Volume
31
Category
Article
ISSN
0167-6997

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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and gemcitabine have single‐agent activity in breast and ovarian carcinoma patients. We conducted a Phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in patients with advanced malignancie