Phase II study of weekly Kahalalide F in patients with advanced malignant melanoma
✍ Scribed by Salvador Martín-Algarra; Enrique Espinosa; Jordi Rubió; Juan José López López; José Luis Manzano; Lorenzo Alonso Carrión; Arrate Plazaola; Adnan Tanovic; Luis Paz-Ares
- Book ID
- 116429919
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 108 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0959-8049
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The National Cancer Institute of Canada Clinical Trials Group conducted a phase II study of spirogermanium given daily for 5 days every 3 weeks to previously untreated patients with malignant melanoma. In 21 evaluable patients one complete response was seen (response rate 5%). Disease progression oc
Nineteen patients with advanced malignant melanoma were treated with a combination of recombinant alfa-interferon (a-IFN) and vinblastine (VBL). The a-IFN was administered subcutaneously daily at an initial dose of 3 X lo6 IU escalating to a maximal dose of 9 X lo6 U daily for the first 10 weeks fol