Phase II study of epirubicin in advanced malignant melanoma
β Scribed by Massimo Lopez; Carlo-Federico Perno; Paola Papaldo; Luigi Lauro; Fabrizio Ganzina; Aldo Barduagni
- Publisher
- Springer US
- Year
- 1984
- Tongue
- English
- Weight
- 194 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0167-6997
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Forty-two previously untreated patients with metastatic malignant melanoma were randomized to receive DTIC at a dose of 250 mg/m2/day 4 IV on days 1-5 or the same drug plus epirubicin (Epi-DX) at a dose of 90 mg/m2 on day 1. Cycles were repeated every 3 weeks. Partial responses were observed in two
Nineteen patients with advanced malignant melanoma were treated with a combination of recombinant alfa-interferon (a-IFN) and vinblastine (VBL). The a-IFN was administered subcutaneously daily at an initial dose of 3 X lo6 IU escalating to a maximal dose of 9 X lo6 U daily for the first 10 weeks fol