Phase I/II study of paclitaxel, carboplatin, and methotrexate in advanced transitional cell carcinoma: a well-tolerated regimen with activity independent of p53 mutation
β Scribed by Martin J Edelman; Frederick J Meyers; Tim R Miller; Stephen G Williams; Regina Gandour-Edwards; Ralph W deVere White
- Book ID
- 117266365
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 130 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0090-4295
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## Abstract ## BACKGROUND The purpose of the study was to assess the efficacy and toxicity of carboplatin and paclitaxel administered every 3 weeks in patients with advanced urothelial carcinoma, previously treated with cisplatinβbased therapy. ## METHODS Eligibility included metastatic or local
## Abstract ## BACKGROUND Platinumβbased regimens have improved response rates and survival in patients with advanced transitional cell carcinoma (TCC) of the urothelial tract. However, the toxicities of platinumβbased chemotherapy are considerable. Regimens with reduced toxicity that are applicab