## Background: Topotecan is a new antineoplastic agent with a broad spectrum of activity. the purpose of this phase i trial was to define the maximum tolerated dose of topotecan when added to the widely used combination of paclitaxel and carboplatin. ## Methods: Patients with advanced cancer that
Phase I Trial of Paclitaxel, Carboplatin, and Methotrexate With Granulocyte Colony-Stimulating Factor and Leucovorin in Advanced Transitional Cell Carcinoma
โ Scribed by Edelman, M.H.; Meyers, F.J.; Houston, J.; Lauder, I.
- Book ID
- 122376882
- Publisher
- Lippincott Williams and Wilkins
- Year
- 1999
- Tongue
- English
- Weight
- 211 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0022-5347
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Background. A combination of carboplatin (CBDCA) and oral etoposide is better tolerated than, and as effective as, more aggressive chemotherapy regimens in patients with advanced nonsmall cell lung cancer (NSCLC). A Phase 1/11 study was conducted to determine whether the addition of the granulocyte-
The primary purpose of this study was to establish the maximum tolerated dose (MTD) of intravenous melphalan in combination with paclitaxel and cisplatin plus granulocyte-colony stimulating factor (G-CSF) in patients with suboptimal advanced epithelial ovarian carcinoma or primary peritoneal carcino
## BACKGROUND. Due to lack of success with standard chemotherapy and only modest